P-116DOES THE MODIFIED FRAILTY INDEX SCORE PREDICT OUTCOME IN PATIENTS UNDERGOING VIDEO-ASSISTED THORACIC SURGERY PLEURODESIS FOR MALIGNANT PLEURAL EFFUSION?
Interactive Cardiovascular and Thoracic Surgery
Thirty-one patients (2.1%) had to be re-operated. Postoperative complications developed in 409 patients (28.3%). Most frequent complications were Clavien-Dindo category 1 or 2, with air leakage (n = 93, 6.3%), urinary retention (n = 44, 3%), pulmonary infection (n = 43, 2.9%), arrhythmia (n = 41, 2.8%), atelectasis (n = 39, 2.6%), pleural effusion (n = 11, 0.7%), recurrent paralysis (n = 10, 0.7%) and chylothorax (n = 10, 0.7%). Mean postoperative hospital stay was 6.3 [0-91] days. A total of
... patients died within 3 months of surgery (2.7%). Conclusions: Robotic technology is increasingly reported in thoracic surgery in France. It appears to be safe and efficient with few severe postoperative complications. In the near future, a comparison between robotic-assisted and conventional video-assisted thoracic surgery is warranted in terms of patient benefits, logistics and costs. Disclosure: J. Baste: Proctor for Intuitive Surgery, Medtronic and Ethicon. M. Durand, N. Santelmo and C. Doddoli: Proctors for Intuitive Surgery. Objectives: The aim of current study was to investigate the impact of early oral feeding (EOF) on high-mobility group box chromosomal protein 1 (HMGB-1) after McKeown minimally invasive oesophagectomy (MIE) for cancerÁ Methods: This study was based on a single centre randomized controlled trial in Henan Cancer Hospital (NCT01998230). Patients with oesophageal cancer who received McKeown MIE were randomly allocated to a group starting EOF on postoperative day (POD) 1 and another group that remained nil by mouth until 7 days after surgery (late oral feeding, LOF group). A total of 280 patients were included in this study. We chose 46 patients including 25 patients in EOF group and 21 patients in LOF group to test HMGB-1. Serum HMGB-1 concentrations were measured by enzyme-linked immunosorbent assay. Blood samples were obtained before, and at POD1, POD3 and POD5. HMGB-1 changes between the 2 groups and within groups were evaluated. Results: EOF group and LOF group exhibited similar preoperative HMGB-1 level. The level of HMGB-1 increased significantly at POD1 and POD3 compared with preoperative level (all P < 0.01). At POD5 the level of HMGB-1 decreased compared with POD1 and POD3. At PODs 3 and 5, the level of HMGB-1 in the EOF group was significantly lower than those in the LOF group (all P < 0.05). Conclusions: Compared to conventional rehabilitation program, EOF could decrease HMGB-1 after McKeown MIE.