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Imaging Reveals the Connection Between Spontaneous Coronary Plaque Ruptures, Atherothrombosis, and Myocardial Infarctions in HypoE/SRBI-/- Mice
2016
Journal of Nuclear Medicine
The hyperlipidemic mouse model HypoE/SRBI −/− has been shown to develop occlusive coronary atherosclerosis followed by myocardial infarctions and premature deaths in response to high-fat, highcholesterol diet (HFC). However, the causal connection between myocardial infarctions and atherosclerotic plaque rupture events in the coronary arteries has not been investigated so far. The objective of this study was to assess whether diet-induced coronary plaque ruptures trigger atherothrombotic
doi:10.2967/jnumed.115.171132
pmid:27127225
fatcat:errlz6mgqbc7xkhj2trf2ovtke