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DIASTOLIC DYSFUNCTION – NEGATIVE PROGNOSTIC FACTOR IN PATIENTS WITH HEPATIC CIRRHOSIS
Disfuncţia diastolică – factor de prognostic negativ la pacienţii cu ciroză hepatică

Alexandru Mihailovici, Spitalul Clinic Judeţean de Urgenţă, Universitatea de Medicină şi Farmacie, Craiova, Maria Buşe, Ionuţ Donoiu, Octavian Istrătoaie, Diana Tudoraşcu, Dan Ionuţ Gheonea, Spitalul Clinic Judeţean de Urgenţă, Craiova, Disciplina Cardiologie, Universitatea de Medicină şi Farmacie, Craiova, Disciplina Cardiologie, Universitatea de Medicină şi Farmacie, Craiova, Disciplina Medicină Internă, Universitatea de Medicină şi Farmacie, Craiova, Disciplina Medicină Internă, Gastroenterologie, Universitatea de Medicină şi Farmacie, Craiova
2017 Revista Medicală Română  

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Objectives. To evaluate the left ventricular diastolic function in patients with cirrhosis and to establish its relation to the degree of severity of liver disease as well as to biological markers of cardiac dysfunction. Methods. We included 72 patients diagnosed with liver cirrhosis in different degrees of disease progression. Cardiac parameters were evaluated by two-dimensional echocardiography and color Doppler. Results. In terms of diastolic echocardiographic function, 26 patients had
more » ... diastolic function, 36 had grade 1 diastolic dysfunction, 8 had grade 2 dysfunction, and 2 patients had grade 3. Diastolic dysfunction was unrelated to age, gender and etiology of cirrhosis. Of all the echocardiographic parameters, left ventricular hypertrophy, right cavity dimensions, E wave deceleration time, left atrial volume were significantly higher in patients with diastolic dysfunction, correlated with the severity of cirrhosis. Significantly elevated NT-proBNP and TnI were seen among the patients with diastolic dysfunction. Conclusions. The present study shows that although diastolic dysfunction is common in cirrhosis, it is usually incipient and most often correlates with the severity of the liver disease (Child-Pugh class).
doi:10.37897/rmj.2017.2.3 fatcat:3xee2abwjvdcldrhazzguhc5dq
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Alexandru Mihailovici, Spitalul Clinic Judeţean de Urgenţă, Universitatea de Medicină şi Farmacie, Craiova, Maria Buşe, Ionuţ Donoiu, Octavian Istrătoaie, Diana Tudoraşcu, Dan Ionuţ Gheonea, Spitalul Clinic Judeţean de Urgenţă, Craiova, Disciplina Cardiologie, Universitatea de Medicină şi Farmacie, Craiova, Disciplina Cardiologie, Universitatea de Medicină şi Farmacie, Craiova, Disciplina Medicină Internă, Universitatea de Medicină şi Farmacie, Craiova, Disciplina Medicină Internă, Gastroenterologie, Universitatea de Medicină şi Farmacie, Craiova. "DIASTOLIC DYSFUNCTION – NEGATIVE PROGNOSTIC FACTOR IN PATIENTS WITH HEPATIC CIRRHOSIS." Revista Medicală Română 64.2 (2017) 110-116