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Parkinson′s disease (PD) is a well-known neurodegenerative disease. Recently, the role of gingipains from Porphyromonas gingivalis was implicated in Alzheimer′s disease. Here we present evidence of systemic inflammation, accompanied by hypercoagulation; we also show that ginipains from P. gingivalis and its LPS may foster abnormal clotting, and that ginipains are present in PD blood, and thus that ginipain′s action on blood may be relevant to PD pathology. Bloods from both PD and healthy blooddoi:10.1101/646307 fatcat:r2pgpapthnez5a4xx67eobehk4