Review of Drug Repositioning Approaches and Resources

Hanqing Xue, Jie Li, Haozhe Xie, Yadong Wang
2018 International Journal of Biological Sciences  
Drug discovery is a time-consuming, high-investment, and high-risk process in traditional drug development. Drug repositioning has become a popular strategy in recent years. Different from traditional drug development strategies, the strategy is efficient, economical and riskless. There are usually three kinds of approaches: computational approaches, biological experimental approaches, and mixed approaches, all of which are widely used in drug repositioning. In this paper, we reviewed
more » ... nal approaches and highlighted their characteristics to provide references for researchers to develop more powerful approaches. At the same time, the important findings obtained using these approaches are listed. Furthermore, we summarized 76 important resources about drug repositioning. Finally, challenges and opportunities in drug repositioning are discussed from multiple perspectives, including technology, commercial models, patents and investment.
doi:10.7150/ijbs.24612 pmid:30123072 pmcid:PMC6097480 fatcat:yvyuqvjcivd3bhkej6gyfrb42u