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Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus disease-2019 (COVID-19) pandemic is an example of a multi-systemic infectious disease. In addition of respiratory manifestations and severe pneumonia related to COVID-19, The SARS-CoV-2 can penetrate into the central nervous system (CNS) and participate in the induction ofdoi:10.37897/rjn.2021.3.3 fatcat:4r7dhg5zkzcdfgoi3tfkcsq33q