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Virology, pathophysiology and neuroinvasion mechanisms of SARS-CoV-2: A mini literature review

Arash Pourgholaminejad, Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Samaneh Kazemi, Alia Saberi, Deputy of Research and Technology, Guilan University of Medical Sciences, Rasht, Iran, Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2021 Romanian Journal of Neurology  

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Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus disease-2019 (COVID-19) pandemic is an example of a multi-systemic infectious disease. In addition of respiratory manifestations and severe pneumonia related to COVID-19, The SARS-CoV-2 can penetrate into the central nervous system (CNS) and participate in the induction of
more » ... eurological disorders and promote some neuropathies. Knowledge of the spectrum of SARS-CoV-2-associated pathophysiology and neuroinvasion pathways will lead to improved clinical outcomes and better treatment algorithms. The aim of this review is to summarize available knowledge on the identification of virology, neuroinvasion mechanisms and the pathophysiology of SARS-CoV-2 in the CNS.
doi:10.37897/rjn.2021.3.3 fatcat:4r7dhg5zkzcdfgoi3tfkcsq33q
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Arash Pourgholaminejad, Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Samaneh Kazemi, Alia Saberi, Deputy of Research and Technology, Guilan University of Medical Sciences, Rasht, Iran, Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. "Virology, pathophysiology and neuroinvasion mechanisms of SARS-CoV-2: A mini literature review." Romanian Journal of Neurology 20.3 (2021) 288-291