Tobacco Causes Human Cancers--A Concept Founded on Epidemiology and an Insightful Experiment Now Requires Translation Worldwide

L. A. Loeb
2016 Cancer Research  
The recognition that tobacco smoke is carcinogenic led to the most significant and successful effort at reducing cancer incidence in human history. A major milestone of this effort was the publication in Cancer Research by Wynder and colleagues, which demonstrated the ability of tobacco tars to produce tumors in mice. This study provided a powerful link between the epidemi-ology of cancer and mechanisms of carcinogenesis. This commentary asserts that we have a moral obligation to translate our
more » ... n to translate our success in reducing lung cancer in the United States to the 1.25 billion smokers throughout the rest of the world.
doi:10.1158/0008-5472.can-16-0149 pmid:26880808 fatcat:dos34w4gprcmfmml2f4ies3ifq