The clinical significance of cutaneous metastasis and paraneoplastic skin lesions in ovarian cancer. A rare but not minor manifestation

Nikolaos Machairiotis, Nikolaos Thomakos, Anastasios Malakasis, Alexandros Rodolakis
2018 Hellenic Journal of Obstetrics and Gynecology  
Ovarian cancer results in the formation and proliferation of abnormal cells that have the ability to proliferate faster than normal/typical ovarian cells and then spread to other parts of the body either in a local or in a systemic way. The areas to which the metastases of ovarian cancer can be located include the lining of the abdomen, lining of the bowel and bladder, lymph nodes, lungs, liver and in very rare cases the skin. We performed a review of the literature in order to find and
more » ... the cutaneous manifestations of the different types of ovarian cancer. Skin is a rather unusual organ for the localization of metastatic ovarian cancer but it must not be overseen. Cutaneous metastasis from carcinoma are relatively uncommon in clinical practice but they are very important to recognize. Cutaneous metastasis may herald the diagnosis of internal malignancy, and early recognition can lead to accurate and prompt diagnosis and timely treatment. However, a high index of suspicion is required because the clinical findings may be subtle. Our understanding of skin disease remains mainly descriptive rather than pathophysiologic. The variation and the multipotent skin expression of the ovarian as well as other intrabdominal, supradiaphragmatic malignancies reveal their similarity to autoimmune diseases, leading to the inert question if it is immunologic modulated.
doi:10.33574/hjog.1503 fatcat:udeqpi5zajfvbl2owifxwmi4hm