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Type I interferons in host defence and inflammatory diseases
Lupus Science and Medicine
Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are beneficial or detrimental to the individual depending on whether IFN pathway activation is transient or sustained. Determinants of IFN production and its functional consequences include the nature of the microbial or nucleic acid stimulus, the type of nucleic acid sensor involved in inducing IFN, the predominant subtype of type I IFN produced and the immune ecology of the tissue at the time of IFNdoi:10.1136/lupus-2019-000336 fatcat:u7rewtvsufbqxamyu2ygipykb4