Effect of FK506 on Functional Recovery After Facial Nerve Injury in the Rat

Cory Yeh, Daniel Bowers, Tessa A. Hadlock
2007 Archives of Facial Plastic Surgery  
Objective: To examine the effect of the immunosuppressive agent FK506 on the rate of functional recovery of the rat facial nerve after crush injury. Methods: Forty rats underwent facial nerve crush injury and were randomly assigned to 4 experimental groups: isotonic sodium chloride solution control, FK binding protein 52 (FKBP-52) antibody control, FK506, and FK506 and FKBP-52 antibody. Rats underwent daily recovery testing from postoperative day 9 until postoperative day 21 by videotaping 3
more » ... idated variables in this model: blink reflex return, vibrissial fibrillation loss, and return of vibrissial sweeping symmetry. Results: FK506-treated animals demonstrated improved recovery in all 3 variables compared with control animals. The FK506 and FKBP-52 antibody group demonstrated improved recovery of only the return of the blink reflex. Conclusions: FK506 accelerated functional recovery of facial nerve function after crush injury. Neuroregeneration was inhibited by FKBP-52 antibody in the rat midface but not the upper face. FK506 may be a viable adjuvant treatment for facial nerve neurapraxic injury.
doi:10.1001/archfaci.9.5.333 pmid:17875826 fatcat:jcupgddfdrglljbrbvat6igug4