A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit <a rel="external noopener" href="http://pdfs.semanticscholar.org/aeda/9a5addccd142f222ae837f5f438547f0c840.pdf">the original URL</a>. The file type is <code>application/pdf</code>.
Asymmetry between pushing and pulling for crawling cells
<span title="2013-02-28">2013</span>
<i title="American Physical Society (APS)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nuk2stxzvvhf7ljciu325kj77m" style="color: black;">Physical Review E</a>
</i>
Preserved Fulltext
Other Versions
<span title="2013-02-16">2013</span>
<span class="release-stage" >pre-print</span>
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1302.4002v1">arXiv:1302.4002v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j3kbg2g3kvat5fmkqjmore4hwu">fatcat:j3kbg2g3kvat5fmkqjmore4hwu</a> </span>
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1302.4002v1">arXiv:1302.4002v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j3kbg2g3kvat5fmkqjmore4hwu">fatcat:j3kbg2g3kvat5fmkqjmore4hwu</a> </span>
Eukaryotic cells possess motility mechanisms allowing them not only to self-propel but also to exert forces on obstacles (to push) and to carry cargoes (to pull). To study the inherent asymmetry between active pushing and pulling we model a crawling acto-myosin cell extract as a 1D layer of active gel subjected to external forces. We show that pushing is controlled by protrusion and that the macroscopic signature of the protrusion dominated motility mechanism is concavity of the force velocity
<span class="external-identifiers">
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1103/physreve.87.022720">doi:10.1103/physreve.87.022720</a>
<a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23496561">pmid:23496561</a>
<a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6p4l73dtefboviu5yyxv3s5n4a">fatcat:6p4l73dtefboviu5yyxv3s5n4a</a>
</span>
more »
... elation. Instead, pulling is driven by protrusion only at small values of the pulling force and it is replaced by contraction when the pulling force is sufficiently large. This leads to more complex convex-concave structure of the force velocity relation, in particular, competition between protrusion and contraction can produce negative mobility in a biologically relevant range. The model illustrates active readjustment of the force generating machinery in response to changes in the dipole structure of external forces. The possibility of switching between complementary active mechanisms implies that if necessary 'pushers' can replace 'pullers' and visa versa.
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190302032938/http://pdfs.semanticscholar.org/aeda/9a5addccd142f222ae837f5f438547f0c840.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext">
<button class="ui simple right pointing dropdown compact black labeled icon button serp-button">
<i class="icon ia-icon"></i>
Web Archive
[PDF]
<div class="menu fulltext-thumbnail">
<img src="https://blobs.fatcat.wiki/thumbnail/pdf/ae/da/aeda9a5addccd142f222ae837f5f438547f0c840.180px.jpg" alt="fulltext thumbnail" loading="lazy">
</div>
</button>
</a>
<a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1103/physreve.87.022720">
<button class="ui left aligned compact blue labeled icon button serp-button">
<i class="external alternate icon"></i>
aps.org
</button>
</a>