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Alkyl Formates as Transfer Hydroalkylation Reagents and Their Use in the Conversion of Imines to Alkylamines
[post]
2022
unpublished
Preserved Fulltext
Easily accessible via a simple esterification of alcohols with formic acid, alkyl formates are used as a novel class of transfer hydroalkylation reagents, CO2 acting as a traceless linker. As a proof-of-concept, their reactivity in the transfer hydroalkylation of imines is investigated, using a ruthenium-based catalyst and LiI as promoter to cleave the C−O σ–bond of the formate scaffold. Providing tertiary amines, the reaction displays a reverse and complementary regioselectivity compared to
doi:10.26434/chemrxiv-2022-c497b-v2
fatcat:fkcof5moqzbnrmpnvd5bs5ph44