264 patient will greedily and gratefully imbibe. The first three or four pills will be probably ejected, but the subsequent doses will be retained, and their good effect, in conjunction with the water, speedily perceived. " With regard to the modus operandi of these remedies, I apprehend that strychnine, being the most powerful tonic known, acts in that capacity on the prostrate nervous system; and t: at the cold water in the first place replaces the loss of the fluids, and in the next, by its

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... oldness, constringes the papillae of the mucous membrane, thus suppressing their outpourings ; lastly, that, by its volume, distends and gives tone to the otherwise empty and flaccid intestinal tube.