Concomitant Dosing with Antagonists Improved Tacrolimus (FK506)-Induced Nephrotoxicity in Rats

Toshiyuki Fujii, Takashi Mitamura, Atsushi Yamada, Shiro Fujihira, Kaname Ohara, Yasuhiro Mine
1996 Journal of Toxicologic Pathology  
FK506-induced nephrotoxicity has been reported to occur by arteriolar constriction of the renal cortex, which is induced through the production of such vasoactive factors as thromboxane A2 (TX A2), renin, 84, 1996)
doi:10.1293/tox.9.277 fatcat:hnvhayknzvadjnxu7fo3yk6vje