A new pair of enantiomeric lignans from the fruits of Morinda citrifolia and their absolute configuration

Wen-Jian Liu, Yue-Juan Chen, Dan-Na Chen, Ya-Ping Wu, Yu-Jie Gao, Jing Li, Wen-Jun Zhong, Lin Jiang
2017 Figshare  
A new pair of sesamin-type lignan enantiomers (±)-morifolia A (1a/1b) together with eight known analogues (2–9) were isolated from the fruits of Morinda citrifolia. Their structures were established by spectroscopic data and the absolute configurations of 1a/1b were determined by ECD calculation. All compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages, and compounds 1a, 1b, 2–4 and 7–9 exhibited
more » ... nounced inhibition with IC50 values in the range of 1.97–8.01 (μM, being more active than the positive control, quercetin (IC50 = 15.32 (M).
doi:10.6084/m9.figshare.5384029 fatcat:oj7e3amajjakzc7emexb7pjx44