Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population

X.F. Li, Y.X. Chen, W.W. Ye, X.F. Tao, J.H. Zhu, S. Wu, L.Q. Lou
2014 Genetics and Molecular Research  
The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in 460 HCC patients and 463 controls using the created restriction site-polymerase chain reaction method. Our results indicate that the c.1471G>A variant could be detected
more » ... could be detected and that the allele and genotype frequencies were statistically different between cases and controls. The AA genotype was strongly associated with increased HCC susceptibility as compared with the GG wild genotype (OR = 2.214, 95%CI = 1.493-3.283, χ 2 = 15.97, P < 0.0001). In addition, significantly increased HCC susceptibility was also found in a dominant and recessive model (P < 0.01). The allele A could contribute to HCC susceptibility compared with the G allele (OR = 1.480, 95%CI = 1.224-1.789, χ 2 = 16.44, P = 0.0001). Results from this study indicate 161 ©FUNPEC-RP Genetics and Molecular Research 13 (1): 160-166 (2014) XRCC1 polymorphism associated with hepatocellular carcinoma that the XRCC1 c.1471G>A polymorphism is associated with HCC susceptibility in the Chinese Han population. Future studies on larger populations are essential to confirm this association.
doi:10.4238/2014.january.10.7 pmid:24446299 fatcat:b3sh7tdqbvgyvgjrodjz5zkkvm