Malformations of cortical development: current concepts and advanced neuroimaging review

Celi Santos Andrade, Claudia da Costa Leite
2011 Arquivos de Neuro-Psiquiatria  
Malformations of cortical development (MCD) result from disruptions in the complex process of the human brain cortex formation and are highly associated to severe epilepsy, neurodevelopmental delay and motor dysfunction. Nowadays, magnetic resonance imaging (MRI) is the cornerstone of the work-up of patients with epilepsy and modern advanced imaging techniques have improved not only our ability to detect and characterize cortical malformations, but also in identifying associated functional
more » ... ted functional abnormalities that are far beyond the structural visualized lesions. Herein, we address the most currently used classifications of MCD and make a concise review of the embryological process of cortical development. Our main goal is to summarize recent advances and new trends in diagnostic imaging techniques concerning MCD. Thereafter, follows a brief discussion of specific disorders and their radiological features.
doi:10.1590/s0004-282x2011000100024 pmid:21359436 fatcat:kwiq7f3fcfhkbcltfm4pmlf6si