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Role of Coccinia indica in the prevention and management of breast cancer: A review

Rinki Kumari, Junior Research Fellow under DST project and Ph.D Scholar, Department of Kriya Sharir, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Aruna Agrawal, Malika Tiwari, H.S. Shukla, Govind P Dubey, Professor, Department of Kriya Sharir and Coordinator, Faculty of A yurveda, Institute of Medical Sciences, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Associate Professor & Head, Department of Surgical Oncology, Institute of Medical Science, Banaras Hindu Unive rsity (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Distinguished Professor, Department of Surgical Oncology, Institute of Medical Science, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Distinguished Professor, Advanced Centre for Traditional and Genomic Medicine, Institute of Medical Science, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India
2016 Journal of Ayurvedic and Herbal Medicine  

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Cucurbitacin B is isolated from the fruit of Coccinia indica, have reported for treatment of several types of cancer due to its anticancer and antioxidant effect. Cucurbitacin B, inducing cell cycle arrest at G2/M as well as apoptosis. It can act as anti-proliferative agent for breast cancer cells in vitro and in vivo and reduces the ferrocynaide to ferrous. Cucurbitacin B inhibits telomerase activity in several breast cancer cell lines through down regulation of both the hTERT and c -Myc
more » ... sion. The expression of the hTERT gene directly depends on the telomerase activity as the hTERT protein, is the catalytic rate-limiting determinant subunit of telomerase. Estrogen receptor activates a number of cellular signal transduction and also ERK/MAPK pathway. It leads to the translocation of activated MAP kinase to the nucleus where it regulates the expression of a number of transcription factors. Including pertinently, c -Myc but when cell lines treated with cucurbitacin B, directly modulates either the estrogen receptor or subsequent signalling pathway and the down regulate JAK/STAT pathway. Whereas some different biological pathway exist in estrogen negative cells, where c -Myc is primarily controlled at the level of RNA stability. However, cucurbitacin B exerts anticancer activity and inhibit the telomerase and induced apoptosis.
doi:10.31254/jahm.2016.2207 fatcat:5pyljsteivce5nvvx6sm7v3z4y
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Rinki Kumari, Junior Research Fellow under DST project and Ph.D Scholar, Department of Kriya Sharir, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Aruna Agrawal, Malika Tiwari, H.S. Shukla, Govind P Dubey, Professor, Department of Kriya Sharir and Coordinator, Faculty of A yurveda, Institute of Medical Sciences, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Associate Professor & Head, Department of Surgical Oncology, Institute of Medical Science, Banaras Hindu Unive rsity (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Distinguished Professor, Department of Surgical Oncology, Institute of Medical Science, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India, Distinguished Professor, Advanced Centre for Traditional and Genomic Medicine, Institute of Medical Science, Banaras Hindu University (IMS, BHU), Varanasi, Uttar Pradesh-221005, India. "Role of Coccinia indica in the prevention and management of breast cancer: A review." Journal of Ayurvedic and Herbal Medicine 2.2 (2016) 56-60