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the heritability of hypertension and large vessel atherosclerosis  . Genetic research makes use of two main approaches to identify gene variants related to disease: linkage and association studies. Linkage relies on the fact that the recombination of gene sequences is more likely to occur between loci that are further apart on the genome than between loci closer together. Thus, the coinheritance of two distant loci that occurs more often than would be expected by chance indicates linkage ofdoi:10.1159/000199467 pmid:19202334 fatcat:rfkhq7wj6fdfjhleknjdha2xny