Association of maternal folate and vitamin B12 in early pregnancy with gestational diabetes mellitus: a prospective cohort study [post]

Xiaotian Chen, Yi Zhang, Hongyan Chen, Yuan Jiang, Yin Wang, Dingmei Wang, Mengru Li, Yalan Dou, Xupeng Sun, Guoying Huang, Weili Yan
2020 unpublished
<strong>OBJECTIVE</strong> <p>To investigate the association of folate and<b> </b>vitamin B<sub>12 </sub>in early pregnancy with gestational diabetes mellitus (GDM) risk.</p> <p> </p> <p><strong>RESEARCH DESIGN AND METHODS</strong> </p> <p><a></a><a>The data of this study were from a sub-cohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cell (RBC) folate and vitamin B<sub>12</sub> measurements at recruitment (between </a><a>9-13 gestational weeks</a>)
more » ... and those with three samples available for glucose measurements under oral glucose tolerance test (OGTT). GDM was diagnosed between 24-28 weeks gestation. <a>Odds ratio (OR) </a>of having a GDM and 95% confidence interval (CI) was used to quantify the association. </p> <p> </p> <p><strong>RESULTS</strong> </p> <p><a></a><a>A total of 1,058 pregnancies were included and 180 GDM occurred (17.01%).</a> RBC folate and vitamin B<sub>12 </sub>were significantly higher in pregnancies with GDM than those without GDM (<i>P</i> values were 0.045 and 0.002 respectively), and positively correlated with 1-hour and 2-hour serum glucose. Daily folic acid supplementation in early pregnancy increases the risk of GDM, OR (95% CI) was 1.73 (1.19-2.53), <i>P</i>=0.004. Compared with RBC folate <400 ng/mL, pregnancies with RBC folate ³600 ng/mL was associated with approximately 1.60-fold higher odds of GDM, the adjusted OR (95% CI) was 1.58 (1.03-2.41), <i>P</i>=0.033. A significant trend of risk effect on GDM risk across categories of RBC folate was observed (<i>P</i><sub>trend</sub> =0.021). Vitamin B<sub>12</sub> was significantly associated with GDM risk (OR =1.14 per 100 pg/ml, <i>P</i>=0.002). No significant association of serum folate and percentile ratio of RBC folate/vitamin B<sub>12</sub> with GDM was observed.</p> <p> </p> <p><strong>CONCLUSIONS</strong> </p> <p><a>Higher </a>maternal RBC folate and vitamin B<sub>12 </sub>levels<sub> </sub>in early pregnancy are significantly associated with GDM risk, while the balance of folate/vitamin B<sub>12</sub> is not significantly associated with GDM.</p>
doi:10.2337/figshare.13079519 fatcat:4ouhtiecdfcjfnb6ltvpweqlsm