Evaluation of Cellular Immune Responses to Mycobacterial Antigens among Immigrants from South-East Asian Countries in South Korea

Hye Jon Lee
2013 Mycobacterial Diseases  
Healthy immigrant females from Vietnam and Cambodia with their Korean spouses were recruited to measure IFN-γ responses to mycobacterial antigens, using a 6-day whole blood assay. The results showed that there is no significant difference in the proportion of positive IFN-γ responses to mycobacterial antigens, PPD, ESAT-6 and CFP-10, between the Korean males and immigrant females aged 30-<40 years. The whole blood assay using mycobactierial antigens can be a useful tool to detect the prevalence
more » ... tect the prevalence of current and past infection with M. tuberculosis as shown in healthy immigrants and their Korean spouses. As also found in this study, if an IFN-γ response to ESAT-6 and CFP-10 is an actual indication of latent infection with M. tuberculosis, the chance of past infection in Korean males is as high as in the immigrant females aged 30-<40. Thus, unexpectedly immigrants from Asian countries where TB incidence are higher do not pose a significant health threat to Korean spouses older than 30 year olds.
doi:10.4172/2161-1068.1000114 fatcat:37elayrqdbco5jirgoi6egrc4y