W e compared the result of proximal humerous and distal humerous malignant tumors in operation with Howmedica Modular Resection System (HMRS) prosthesis. This report was based on clinical results of 2 patients with malignant bone tumors of humerus who were treated with HMRS by the authors. The patient in case 1, a 51 year-old man with chondrosarcoma of the right proximal humerus, received wide resection and reconstruction with HMRS prosthesis. Four months after surgery, the prosthesis was

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... d because of rupture of the wound by foreign body reaction. And vascularized fibula graft was performed. The patient in case 2, a 76 year-old man with matastatic bone tumor of the right distal humerus, received marginal resection and reconstruction with HMRS prosthesis. At the last follow-up, seven months after surgery, symptoms of inflammation and infection were not found and the results were good.