Intracerebral Hemorrhage Triggers Interleukin-6 and Interleukin-10 Release in Blood

T. Dziedzic, S. Bartus, A. Klimkowicz, M. Motyl, A. Slowik, A. Szczudlik
2002 Stroke  
and Purpose-Acute brain insult can cause systemic anti-inflammatory response, including antiinflammatory cytokine release. The goal of this study was to determine the serum level of interleukin-6, interleukin-10, and interleukin-13 in patients with intracerebral hemorrhage and to correlate cytokine concentrations with stroke severity. Methods-Thirty patients with intraparenchymal hemorrhage and 16 control subjects were included. Serum samples were collected on the second day of hemorrhagic
more » ... e. Cytokine level was measured with the enzyme-linked immunosorbent assay method. Results-Increased serum levels of interleukin-6 and interleukin-10 were detected in stroke patients. Interleukin-6 and interleukin-10 levels were significantly correlated with Glasgow Coma Scale score. In addition, interleukin-6 level correlated with blood volume and mass effect. Conclusions-Intracerebral hemorrhage is associated with systemic release of anti-inflammatory cytokines. (Stroke. 2002; 33:2334-2335.)
doi:10.1161/01.str.0000027211.73567.fa pmid:12215608 fatcat:lfbrlqoe7vc6dgvsyrbvrzzgme