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Wnt signaling promotes oral but suppresses aboral structures in Hydractinia metamorphosis and regeneration
2010
Development
We studied the role of Wnt signaling in axis formation during metamorphosis and regeneration in the cnidarian Hydractinia. Activation of Wnt downstream events during metamorphosis resulted in a complete oralization of the animals and repression of aboral structures (i.e. stolons). The expression of Wnt3, Tcf and Brachyury was upregulated and became ubiquitous. Rescue experiments using Tcf RNAi resulted in normal metamorphosis and quantitatively normal Wnt3 and Brachyury expression. Isolated,
doi:10.1242/dev.046631
pmid:20685735
fatcat:ulem2rgj3zfohgzc7ep4uir22q