Asymmetric synthesis of (2S)-propranolol using D-mannitol

A Feng, Y Chen, Y Cheng
2013 Journal of Chemical and Pharmaceutical Research   unpublished
It is wildly known that racemic propranolol has dramatically side effects to cardiovascular patients. Thus, it's important to develop a new approach to synthesize the chiral propranolol. In present study, a novel synthetic route to chiral propranolol was carried out, using natural and cheap D-mannitol as starting material. The structures of all the synthesised compounds were confirmed by their IR, 1 H NMR spectral data, and the results of HPLC showed that enantioselectivities up to 99% ee and
more » ... up to 99% ee and chemical yields up to 97% have been obtained.