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Identification a novel subset of alveolar type 2 cells expanding following pneumonectomy and enriched in PD-L1
[article]
2020
bioRxiv
pre-print
Alveolar type 2 (AT2) cells are heterogeneous cells; where specialized AT2 subpopulations within this lineage exhibit stem cell properties. However, the existence of quiescent, immature cells within the AT2 lineage, which get activated during lung regeneration, is unknown. SftpcCreERT2/+; tdTomatoflox/flox mice were used for the labelling of AT2 cells and labeled subpopulations were analyzed by flow cytometry, qPCR, ATAC-seq, gene arrays, pneumonectomy, and culture of precision-cut lung slides.
doi:10.1101/2020.05.20.106005
fatcat:sf5roqsoyba35j3zoamga6ntdy