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Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating powered electronics to multiplex many electrodes to a few external wires. However, existing multiplexed electrode arrays rely on encapsulation strategies that have limited implant lifetimes. Here, we developed a flexible, multiplexed electrodedoi:10.1126/scitranslmed.aay4682 pmid:32269166 pmcid:PMC7478122 fatcat:5vuffcuybbetxb2cj7oci576ee