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PI(3,4,5)P3 produced by the activated PI3-kinase is a key lipid second messenger in cell signaling downstream of insulin. Skeletal muscle and kidney-enriched inositol phosphatase (SKIP) identified as a 5'-inositol phosphatase that hydrolyzes PI(3,4,5) P3 to PI(3,4)P2, negatively regulates the insulin-induced glycogen synthesis in skeletal muscle. However the mechanism by which this occurs remains unclear. To elucidate the function of SKIP in glycogen synthesis, we employed RNAi techniques todoi:10.5483/bmbrep.2009.42.2.119 pmid:19250614 fatcat:xm5jybhdrvfflia4ulb2zet7fe