Global and Local Mutations in Bangladeshi SARS-CoV-2 Genomes [article]

Md Mahbub Hasan, Rasel Das, Md. Rasheduzzaman, Md Hamed Hussain, Nazmul Hasan Muzahid, Asma Salauddin, Meheadi Hasan Rumi, S M Mahbubur Rashid, AMAM Zonaed Siddiki, Adnan Mannan
2020 bioRxiv   pre-print
COVID-19 warrants comprehensive investigations of SARS-CoV-2 genomes to gain new insight about their epidemiology, mutations and pathogenesis. In this study, we compared 207 of SARS-CoV-2 genomes reported from different parts of Bangladesh and their comparison with 467 globally reported sequences to understand the origin of viruses, patterns of mutations, and their apparent impact on pathogenicity. Phylogenetic analyses indicate that GR clade is predominant in Bangladesh and SARS-CoV-2 viruses
more » ... SARS-CoV-2 viruses might have arrived through infected travellers from European countries. We found 2602 mutations including 1602 missense mutations, 612 synonymous mutations, 36 insertions and deletions. In line with the global trend, D614G mutation in spike glycoprotein was predominantly high (95.6%) in Bangladeshi isolates. Previously reported frequent mutations such as P4715L, D614G, R203K, G204R and I300F were also prevalent. Additionally, 87 unique amino acid changes were revealed. The analyses would increase our understanding of variations in virus genomes circulating in Bangladesh and elsewhere.
doi:10.1101/2020.08.25.267658 fatcat:2pxjmn6y6jez7pa432fo6yr3qq