Dengue virus serotype-4 during the 2015-2017 epidemic: emergence of a novel genotype IIa of DENV-4 in the Philippines

Mark Anthony de Vera Luz, Takeshi Nabeshima, Meng Ling Moi, Maria Terrese Alonzo Dimamay, Lady-Anne Suarez Pangilinan, Mark Pierre Sijo Dimamay, Ronald Roll Matias, Cynthia Abad Mapua, Corazon Cerilla Buerano, Ferdinand de Guzman, Edith Sangalang Tria, Filipinas Florendo Natividad (+4 others)
2019 Japanese journal of infectious diseases (Print)  
Dengue remains a major public health problem in the Philippines. In this study, we determined the circulating dengue serotypes in the Philippines during the 2015-2017 outbreaks using a total of 678 serum samples from 537 individual dengue patients. Following an increase in the number of DENV-4 patients in recent years, we conducted a comprehensive molecular and epidemiology analysis on the DENV-4 strains isolated recently in the Philippines. Two genotypes of DENV-4 have been isolated in the
more » ... isolated in the Philippines since 1956: GI and GIIa. The GIIa DENV strains that were isolated in the present study were closely related to a distinct group of GIIa strains that were isolated from the Philippines in 2004. A majority of the isolates of this sub-group have been identified in the Philippines, suggesting that this lineage may have been introduced in the Philippines, and evolved to form the distinct sub-group within GIIa strains. The increase in DENV-4 activity also coincided with the appearance of the GIIa subgroup and the phasing-out of the GI lineage in the Philippines. Overall, our study demonstrates a shift in DENV-4 genotype and epidemic dynamics in a hyperendemic region, suggesting the importance of DENV genetic evolution in establishing and sustaining transmission.
doi:10.7883/yoken.jjid.2019.208 pmid:31474703 fatcat:v5w4ba47pnhlhkccb22wiem5zy