Phase-Variable Genotypes Sweetened by Glycosylation Phenotypes

Nathan J. Weyand, Ann M. Stock
2018 Journal of Bacteriology  
The affordability of bacterial genome sequencing has provided a helpful tool for sequencing large strain collections. Bente Børud (J. Bacteriol. 200:e00794-17, 2018, recently led an effort to analyze the genomes of a collection of oropharyngeal Neisseria meningitidis isolates from 50 healthy individuals. Paired longitudinal isolates from each individual were sequenced. Genome analyses focused on (i) predicting the expression state of phase-variable loci
more » ... hat encode enzymes important for O-linked protein glycosylation and (ii) correlating specific genotypes with glycosylation phenotypes.
doi:10.1128/jb.00316-18 pmid:29866804 fatcat:dg3ejkk2sje5bk36srt7dwr33q