The overlapping development of life sciences and information sciences has promoted the arrival of biological big data era. As one of the fast-growing big data types, biological big data has been profoundly affecting biomedicine and promoting the popularization and application of "precision medicine". However, biological information data cannot exist independently of the basic resource of Biobank. Moreover, the Biobank, which stores human genetic information, is very special. If the human

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... information cannot be strictly protected, it will inevitably cause a shake of the person's subjective status. Therefore, it is very necessary to rationally examine the harm caused by the unreasonable disclosure of current genetic information, and adopt effective countermeasures for the realization the benign operation of the Biobank and enhancement of the welfare of our people.