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Neuroprotective effects of modafinil in a marmoset Parkinson model: behavioral and neurochemical aspects
2006
Behavioural Pharmacology
The psychostimulant modafinil has neuroprotective properties: it prevents striatal ischemic injury, nigrostriatal pathway deterioration after partial transsection and intoxication with 1-methyl-1,2,3,6-tetrahydropyridine (MPTP). The present study determines the protective effects of modafinil in the marmoset MPTP Parkinson model on behavior and on monoamine levels. Twelve marmoset monkeys were treated with a total dose of 6 mg/kg MPTP. Simultaneously, six animals received a daily oral dose of
doi:10.1097/00008877-200609000-00011
pmid:16940766
fatcat:5wtlvz727bhkfk6saerfhyvwhy