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Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
Enhancer of zeste 2 (Ezh2), a SET domain-containing protein, is crucial for development in many model organisms, including early mouse development. In mice, Ezh2 is detected as a maternally inherited protein in the oocyte but its function at the onset of development is unknown. We have used a conditional allele of Ezh2 to deplete the oocyte of this maternal inheritance. We show that the loss of maternal Ezh2 has a long-term effect causing severe growth retardation of neonates despite 'rescue'doi:10.1242/dev.00625 pmid:12900441 fatcat:hlh5vbtssbef5nhdqv6dtgma7u