To Find out the Essentiality of Rv0526 Gene in Virulence of Mycobacterium tube r culosis by using In silico Approaches

Laxman S Meena
<span title="2017-02-11">2017</span> <i title="Peertechz Publications Private Limited"> Open Journal of Bacteriology </i> &nbsp;
Tuberculosis has emerged as a major world health problem, with almost one-third of the world population today infected with Mycobacterium tuberculosis H 37 Rv (M. tuberculosis). This gram-positive bacterium makes so many complications in its eradication completely. We need a proper way to inhibit its pathogenesis. Rv0526 (651bp/ 216 aa) is predicted to be a thioredoxin (Trx) like protein of Rv3673 family form a single transmembrane helix and show similarity to other M. tuberculosis
more &raquo; ... ike proteins Rv1470, Rv1471, Rv1677. Trx are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfi de exchange, and it acts by its specifi c motif Cys37-Cys40 (CXXC). By using several bioinformatics tools, we may predict that Rv0526 may be an important component of cytochrome c maturation complex and show interaction with different other proteins. After knowing such specifi c features of this gene we may predict that mutational studies in Rv0526 gene may open new way towards the drug development.
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