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Solvent-free and one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones using ionic liquid N,N-diethyl-N-sulfoethanammoniumchloride {[Et3N-SO3H]Cl} as a green catalyst

Saeid Azimi, Marziyeh Hariri
unpublished

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https://web.archive.org/web/20151129002406/http://icc.journals.pnu.ac.ir:80/jufile?c2hvd1BERj0xNzMyJl9hY3Rpb249c2hvd1BERiZhcnRpY2xlPTE3MzImX29iPTI4MDg1NmE5NGNhNGQ2ZjMyZTYwN2E4MGE4YWRkNjZm

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In this work, the ionic liquid triethylamine-bonded sulfonic acid {[Et 3 N-SO 3 H]Cl}, N,N-diethyl-N-sulfoethanammonium chloride was used as a green acidic homogeneous catalyst in order to synthesis 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thionesas two categories of heterocycles. The dihidropyrimidineones and dihydropyrimidinethiones derivatives which were synthesized in this method can be regarded as two important categories of heterocyclic compounds with biologic and
more » ... rmacologic activity. The ionic liquid that was used in these reactions acts as Bronsted acid and green homogeneous catalyst. It has N-S bond in its cationic fragment and can be easily synthesised. The advantages of our method are as follow: solvent-free conditions, green process and high isolated yield of products.
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Saeid Azimi, Marziyeh Hariri. "Solvent-free and one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones using ionic liquid N,N-diethyl-N-sulfoethanammoniumchloride {[Et3N-SO3H]Cl} as a green catalyst."