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Motivation Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. Results DREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4,960 drug profiles and ∼2,6K immune gene expression signatures. The tooldoi:10.1093/bioinformatics/btaa727 pmid:32818254 fatcat:uy7at5cz7rhtth27pq2xv33lrq