DREIMT: a drug repositioning database and prioritization tool for immunomodulation

Kevin Troulé, Hugo López-Fernández, Santiago García-Martín, Miguel Reboiro-Jato, Carlos Carretero-Puche, Jordi Martorell-Marugán, Guillermo Martín-Serrano, Pedro Carmona-Sáez, Daniel González-Peña, Fátima Al-Shahrour, Gonzalo Gómez-López, Pier Luigi Martelli
2020 Bioinformatics  
Motivation Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. Results DREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4,960 drug profiles and ∼2,6K immune gene expression signatures. The tool
more » ... natures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables. Availability http://www.dreimt.org Supplementary information Supplementary data are available at Bioinformatics online.
doi:10.1093/bioinformatics/btaa727 pmid:32818254 fatcat:uy7at5cz7rhtth27pq2xv33lrq