1P-238 Search for compounds that modulate tight-junction activity : structural biology and computational approaches(Bioinformatics:Structural genomics, The 47th Annual Meeting of the Biophysical Society of Japan)
1P-238 構造生物学と計算機科学に基づいたタイトジャンクションを制御する化合物の探索(生命情報科学-構造ゲノミクス,第47回日本生物物理学会年会)

Shogo Mase, Kaori Satomura, Natsuko Goda, Yukari Akiyoshi, Takeshi Tenno, Mikio Furuse, Hidekazu Hiroaki
2009 Seibutsu Butsuri  
TheBiophysicalSociety of Japan General IncorporatedAssociation are coarse grained The pepude suhiLh is descnbed as a flexible bead model is movable along the grid points w]]iLh aie set surreunding the protem An arbitrary state of the protem peptide complex is sub]ected te Deldunay tessellation Then the fitness of d pepude coordinat]on to the protem is measured by a four body staustkal pbeudo potential Through 1000 tnals ot a simple hill Lhmbmg optimi7atien the best IS pephde coordinations with
more » ... coordinations with the 1bt 15th highest fitness valueg Are se]ected as candidates for the correct coordination Retnevmg the available seNcntLen
doi:10.2142/biophys.49.s99_3 fatcat:vndc3bix35cudbqrza7yrx3qua