Effects of aflatoxin B1 on DNA damage and P53gene amplification in hepatocyte-like cells differentiated from mesenchymal stem cells and CD34 + cells obtained from human umbilical cord blood

Abdolamir Allameh, Masomeh Ghaderi, Mehdi Fourozandeh-Moghadam, Shahnaz Ismaeili, Masoud Soleimani
2014 Molecular and Biochemical diagnosis (MBD)   unpublished
Differentiation of mesenchymal stem cells (MSCs) to hepatocyte-like cells could be associated with development of liver function factors. The impact of differentiation-dependent changes on DNA integrity is not well understood. In this study, hepatocytes and their progenitor stem cells were treated with aflatoxin B1 (AFB1) and amplification of selected genes linked to DNA damage was examined.