Anti–Glutamic Acid Decarboxylase Limbic Encephalitis Without Epilepsy Evolving Into Dementia With Cerebellar Ataxia

Marisol Mirabelli-Badenier, Giovanni Morana, Francesca Pinto, Antonio Uccelli, Edvige Veneselli, Francesca Maria Battaglia, Roberta Biancheri, Maria Giuseppina Baglietto, Angela Vincent, Maria Margherita Mancardi
2012 Archives of Neurology  
Objectives: To expand the spectrum of the clinical presentation of anti-glutamic acid decarboxylase antibodiesrelated limbic encephalitis and to improve the recognition of this entity. Design: Case study. Setting: University hospital. Patient: An 11-year-old-girl with progressive mood and behavioral disorder, speech impairment, and shortterm memory impairment who manifested cerebellar ataxia with nystagmus during the disease course. Interventions: Blood and cerebrospinal fluid analysis
more » ... autoantibodies, electroencephalography, brain and spinal magnetic resonance imaging, and cognitive and neuropsychological assessment were performed. High-dose methylprednisolone sodium succinate pulses, cycles of intravenous immunoglobulins, mycophenolate mofetil, and rituximab as well as antipsychotics and benzodiazepine were administered.
doi:10.1001/archneurol.2012.234 pmid:22507885 fatcat:yh3uu2kt4nh7viihkiktuqpxla