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EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling
2018
EMBO Molecular Medicine
Osteosarcoma (OS) is a rare tumor of the bone occurring mainly in young adults accounting for 5% of all childhood cancers. Because of the limited therapeutic options, there has been no survival improvement for OS patients in the past 40 years. The epidermal growth factor receptor (EGFR) is highly expressed in OS; however, its clinical relevance is unclear. Here, we employed an autochthonous c-Fos-dependent OS mouse model (H2-c-fosLTR) and human OS tumor biopsies for preclinical studies aimed at
doi:10.15252/emmm.201809408
fatcat:vntanulxmvcqzd6gagzk3rep7u