This review aims to focus attention on the bio-oxidative therapy from the very beginning to date. While ultraviolet blood irradiation is now hardly performed, oxygenozone therapy, after an empirical stage, has grown to be precise and safe. Meantime, there is a renewed interest in the infusion of a dilute solution of hydrogen peroxide in infectious diseases antibiotic-resistant. On a parallel line of research, hyperbaric oxygen therapy has been already accepted by official medicine for the

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... ent of specific diseases. Meantime it is unfortunate that, owing to quacks' interest in using ozonated physiologic saline and in claiming to "cure" type-2 diabetes in 20 days with the unprecise rectal ozone administration, ozone therapy is losing hope to be acknowledged as a valid therapeutic approach.