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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure
[article]
2019
bioRxiv
pre-print
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report the largest GWAS meta-analysis of HF to-date, comprising 47,309 cases and 930,014 controls. We identify 12 independent associations with HF at 11 genomic loci, all of which demonstrate
doi:10.1101/682013
fatcat:5ztsn6aqvjgnheqid2sphkzqxu