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Hippocampal and Entorhinal Cortex Neurofibrillary Tangle Formation in Guamanian Chamorros Free of Overt Neurologic Dysfunction
Journal of Neuropathology and Experimental Neurology
Since first described, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam has represented an important model of age-related neurodegenerative disease. ALS/PDC is characterized neuropathologically by severe widespread involvement by neurofibrillary tangles (NFTs). Over the past 30 years there has been a dramatic decrease in the incidence of ALS and a 10-year increase in the age of onset of ALS and PDC. In 1979, Anderson et al reported evidence of significant NFTdoi:10.1093/jnen/62.4.381 pmid:12722830 fatcat:yt4orjtzqnc63ddmqfkijvcqfa