Association Mapping and Disease: Evolutionary Perspectives [chapter]

Søren Besenbacher, Thomas Mailund, Bjarni J. Vilhjálmsson, Mikkel H. Schierup
2019 Msphere  
In this chapter, we give a short introduction to the genetics of complex diseases emphasizing evolutionary models for disease genes and the effect of different models on the genetic architecture, and we give a survey of the state-of-the-art of genome-wide association studies (GWASs).
doi:10.1007/978-1-4939-9074-0_17 pmid:31278676 fatcat:be4xwoykzzceratsa3g53c5o2a