Introduction Mentoring programs have been planned and executed in Iran particularly in the field of medicine. This study aims to evaluate mentor-mentee relationship in mentoring program at Faculty of Medicine of Tehran University of Medical Science in the 2017-2018 academic year. Methods: This cross sectional study was conducted on all year one medical student enrolled at TUMS in 2017 who attended in mentoring program as a mentee. Data is collected via self-designed questionnaire. Result: 210

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... d 180 persons answered the first and second questionnaire respectively. There was no significant relation between gender of mentor-mentee and features of relationship, although male mentees asked their mentors to visit more than female mentees. (P= 0.000, X ²= 17.62). Significant correlation has been seen between mentee's satisfaction of mentor and any different aspect of mentee's improvement, education (r=0.48) and adaptation to academic environment (r= 0.47). There is not a significant difference in mentees satisfaction between mentees who reached their expectations and mentees who did not (p= 0.758, t= 0.449). Conclusion: This study shows that planning for preparing an efficient structure for mentor-mentee relationship is important, and recommends paying more attention to support new students by introducing the mentoring program to them.