There is considerable variation among children in their perception and tolerance for abdominal pain. This make the evaluation of chronic abdominal pain is difficult (1) . Hereditary angioedema is a rare differential diagnosis to cause abdominal pain in 2 years old child. We report a 2 years old girl with recurrent abdominal pain that require recurrent visit to ER without accompanying skin swelling whose diagnosis as hereditary angioedema and it is the first case reported at this age.