Aurintricarboxylic Acid and Polynucleotides as Novel Inhibitors of Ribonucleotide Reductases

Helga Baumann, Rüdiger Hofmann, Manfred Lammers, Gabrile Schimpff-Weiland, Hartmut Follmann
1984 Zeitschrift für Naturforschung C - A Journal of Biosciences  
Ribonucleoside diphosphate reductases isolated from Escherichia coli, baker's yeast, Ehrlich ascites tumor cells, and a unicellular green alga (Scenedesmus obliquus) are inhibited strongly and uniformly by the polymeric triphenylmethane dye, aurintricarboxylic acid. The molecule appears to interact simultaneously with the enzyme's various nucleotide and catalytic (iron-organic radical) sites. Oligo- and polyribonucleotides are also inhibitory. These reactions serve as models of the probably
more » ... iologic regulation of ribonucleotide reduction exerted by natural inhibitors. Partial characterization of an inhibitor fraction found in wheat seed embryo is described
doi:10.1515/znc-1984-3-413 fatcat:sa3jypbsr5cbpkydwvkrc3fwxu