Effect of Indoxyl Sulfate on Oxidative Stress, Apoptosis, and Monocyte Chemoattractant Protein-1 in Leukocytes

Edgar Ferreira da Cruz, Miguel Cendoroglo, Silvia Regina Manfredi, Maria Eugênia Canziani, Beata Marie Redublo Quinto, Caren Cristina Grabulosa, Nadia Karina Guimarães-Souza, Aline Trevisan Peres, José Tarcísio Giffoni de Carvalho, Marcelo Costa Batista, Maria Aparecida Dalboni
2014 ISRN Oxidative Medicine  
This study showed that indoxyl sulfate, an uremic toxin present in the serum of patients with chronic kidney disease, increases oxidative stress and apoptosis in human neutrophils and reduces the production of monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cell (PBMC). It is possible that these effects caused by this toxin contribute to vascular injury of the endothelium and decreased response to infectious insults, respectively.
doi:10.1155/2014/412389 fatcat:npx3cmmkbjfmflcrwacd5hwcrq