The aim of the present study was to investigate the immunomodulatory activity of ethanolic extract of Malvastrum tricuspidatum A. Gray (MTEE) whole plant in experimental models of immunity. Preliminary immunomodulatory activity was evaluated by studying the effect of MTEE (200, 500, and 1000 mg/kg, p.o.) on immunological organs weight and haematological parameters in Swiss albino mice. The effects were further confirmed in various models like, determination of delayed type hypersensitivity

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... nse (MTEE 200 & 500 mg/kg, p.o.), neutrophil adhesion test and humoral immunity (MTEE 500 mg/kg, p.o.). Sheep red blood cells (SRBC, 0.5×10 9 cells/mL/100g) were used to immunize animals. The total leukocyte count increased significantly after acute administration of MTEE at 1000 mg/kg. Further studies confirmed the immunostimulant potential of MTEE at 500 mg/kg after 14 days of administration. The neutrophil adhesion was increased by 34.19%. Similarly, the antibody titre and DTH were also significantly increased as compared to control. It is concluded that MTEE possesses potential for augmenting immune activity by cellular and humoral mediated mechanisms at 500 mg/kg dose. As it is used for a variety of medicinal purposes, its immunomodulatory effect strengthens the rationale of its use in several Ayuvedic and Unani drugs.